diff --git a/cli/args/config_file.rs b/cli/args/config_file.rs
index 1928d02fb4..66b80b9d40 100644
--- a/cli/args/config_file.rs
+++ b/cli/args/config_file.rs
@@ -1033,20 +1033,37 @@ impl ConfigFile {
   /// JSX import source configuration.
   pub fn to_maybe_jsx_import_source_config(
     &self,
-  ) -> Option<JsxImportSourceConfig> {
-    let compiler_options_value = self.json.compiler_options.as_ref()?;
-    let compiler_options: CompilerOptions =
-      serde_json::from_value(compiler_options_value.clone()).ok()?;
-    let module = match compiler_options.jsx.as_deref() {
-      Some("react-jsx") => Some("jsx-runtime".to_string()),
-      Some("react-jsxdev") => Some("jsx-dev-runtime".to_string()),
-      _ => None,
+  ) -> Result<Option<JsxImportSourceConfig>, AnyError> {
+    let Some(compiler_options_value) = self.json.compiler_options.as_ref() else {
+      return Ok(None);
     };
-    module.map(|module| JsxImportSourceConfig {
+    let Some(compiler_options) =
+      serde_json::from_value::<CompilerOptions>(compiler_options_value.clone()).ok() else {
+        return Ok(None);
+      };
+    let module = match compiler_options.jsx.as_deref() {
+      Some("react-jsx") => "jsx-runtime".to_string(),
+      Some("react-jsxdev") => "jsx-dev-runtime".to_string(),
+      Some("react") | None => {
+        if compiler_options.jsx_import_source.is_some() {
+          bail!(
+            "'jsxImportSource' is only supported when 'jsx' is set to 'react-jsx' or 'react-jsxdev'.\n  at {}",
+            self.specifier,
+          );
+        }
+        return Ok(None);
+      }
+      Some(setting) => bail!(
+        "Unsupported 'jsx' compiler option value '{}'. Supported: 'react-jsx', 'react-jsxdev', 'react'\n  at {}",
+        setting,
+        self.specifier,
+      ),
+    };
+    Ok(Some(JsxImportSourceConfig {
       default_specifier: compiler_options.jsx_import_source,
       module,
       base_url: self.specifier.clone(),
-    })
+    }))
   }
 
   pub fn resolve_tasks_config(
@@ -1609,6 +1626,59 @@ mod tests {
     assert!(ConfigFile::new(config_text, config_specifier).is_err());
   }
 
+  #[test]
+  fn test_jsx_invalid_setting() {
+    let config_text = r#"{ "compilerOptions": { "jsx": "preserve" } }"#;
+    let config_specifier =
+      ModuleSpecifier::parse("file:///deno/tsconfig.json").unwrap();
+    let config = ConfigFile::new(config_text, config_specifier).unwrap();
+    assert_eq!(
+      config.to_maybe_jsx_import_source_config().err().unwrap().to_string(),
+      concat!(
+        "Unsupported 'jsx' compiler option value 'preserve'. Supported: 'react-jsx', 'react-jsxdev', 'react'\n",
+        "  at file:///deno/tsconfig.json",
+      ),
+    );
+  }
+
+  #[test]
+  fn test_jsx_import_source_only() {
+    let config_specifier =
+      ModuleSpecifier::parse("file:///deno/tsconfig.json").unwrap();
+    {
+      let config_text =
+        r#"{ "compilerOptions": { "jsxImportSource": "test" } }"#;
+      let config =
+        ConfigFile::new(config_text, config_specifier.clone()).unwrap();
+      assert_eq!(
+        config.to_maybe_jsx_import_source_config().err().unwrap().to_string(),
+        concat!(
+          "'jsxImportSource' is only supported when 'jsx' is set to 'react-jsx' or 'react-jsxdev'.\n",
+          "  at file:///deno/tsconfig.json",
+        ),
+      );
+    }
+    {
+      let config_text = r#"{ "compilerOptions": { "jsx": "react", "jsxImportSource": "test" } }"#;
+      let config = ConfigFile::new(config_text, config_specifier).unwrap();
+      assert_eq!(
+        config.to_maybe_jsx_import_source_config().err().unwrap().to_string(),
+        concat!(
+          "'jsxImportSource' is only supported when 'jsx' is set to 'react-jsx' or 'react-jsxdev'.\n",
+          "  at file:///deno/tsconfig.json",
+        ),
+      );
+    }
+  }
+
+  #[test]
+  fn test_jsx_import_source_valid() {
+    let config_text = r#"{ "compilerOptions": { "jsx": "react" } }"#;
+    let config_specifier =
+      ModuleSpecifier::parse("file:///deno/tsconfig.json").unwrap();
+    assert!(ConfigFile::new(config_text, config_specifier).is_ok());
+  }
+
   #[test]
   fn test_tsconfig_as_bytes() {
     let mut tsconfig1 = TsConfig::new(json!({
diff --git a/cli/args/mod.rs b/cli/args/mod.rs
index a979aa10c6..68cd3faa74 100644
--- a/cli/args/mod.rs
+++ b/cli/args/mod.rs
@@ -914,11 +914,11 @@ impl CliOptions {
   /// Return the JSX import source configuration.
   pub fn to_maybe_jsx_import_source_config(
     &self,
-  ) -> Option<JsxImportSourceConfig> {
-    self
-      .maybe_config_file
-      .as_ref()
-      .and_then(|c| c.to_maybe_jsx_import_source_config())
+  ) -> Result<Option<JsxImportSourceConfig>, AnyError> {
+    match self.maybe_config_file.as_ref() {
+      Some(config) => config.to_maybe_jsx_import_source_config(),
+      None => Ok(None),
+    }
   }
 
   /// Return any imports that should be brought into the scope of the module
diff --git a/cli/factory.rs b/cli/factory.rs
index 330865744f..28c436e354 100644
--- a/cli/factory.rs
+++ b/cli/factory.rs
@@ -398,7 +398,7 @@ impl CliFactory {
       .resolver
       .get_or_try_init_async(async {
         Ok(Arc::new(CliGraphResolver::new(
-          self.options.to_maybe_jsx_import_source_config(),
+          self.options.to_maybe_jsx_import_source_config()?,
           self.maybe_import_map().await?.clone(),
           self.options.no_npm(),
           self.npm_api()?.clone(),
diff --git a/cli/lsp/documents.rs b/cli/lsp/documents.rs
index d987279dee..2d3bed57af 100644
--- a/cli/lsp/documents.rs
+++ b/cli/lsp/documents.rs
@@ -1219,7 +1219,7 @@ impl Documents {
       });
     let maybe_jsx_config = options
       .maybe_config_file
-      .and_then(|cf| cf.to_maybe_jsx_import_source_config());
+      .and_then(|cf| cf.to_maybe_jsx_import_source_config().ok().flatten());
     let new_resolver_config_hash = calculate_resolver_config_hash(
       &options.enabled_urls,
       options.document_preload_limit,
diff --git a/cli/tools/vendor/mod.rs b/cli/tools/vendor/mod.rs
index 49a984c875..fdea5fc26d 100644
--- a/cli/tools/vendor/mod.rs
+++ b/cli/tools/vendor/mod.rs
@@ -50,7 +50,7 @@ pub async fn vendor(
   let cli_options = factory.cli_options();
   let entry_points =
     resolve_entry_points(&vendor_flags, cli_options.initial_cwd())?;
-  let jsx_import_source = cli_options.to_maybe_jsx_import_source_config();
+  let jsx_import_source = cli_options.to_maybe_jsx_import_source_config()?;
   let module_graph_builder = factory.module_graph_builder().await?.clone();
   let output = build::build(build::BuildInput {
     entry_points,