diff --git a/cli/tests/node_compat/config.jsonc b/cli/tests/node_compat/config.jsonc
index 81463bcaf5..87530d4f5c 100644
--- a/cli/tests/node_compat/config.jsonc
+++ b/cli/tests/node_compat/config.jsonc
@@ -366,6 +366,7 @@
       "test-http-outgoing-message-inheritance.js",
       "test-http-outgoing-renderHeaders.js",
       "test-http-outgoing-settimeout.js",
+      "test-module-run-main.js",
       "test-net-access-byteswritten.js",
       "test-net-better-error-messages-listen-path.js",
       "test-net-better-error-messages-path.js",
diff --git a/cli/tests/node_compat/test/fixtures/run-main.js b/cli/tests/node_compat/test/fixtures/run-main.js
new file mode 100644
index 0000000000..9a081cbbae
--- /dev/null
+++ b/cli/tests/node_compat/test/fixtures/run-main.js
@@ -0,0 +1 @@
+globalThis.foo = 42;
diff --git a/cli/tests/node_compat/test/parallel/test-module-run-main.js b/cli/tests/node_compat/test/parallel/test-module-run-main.js
new file mode 100644
index 0000000000..8e30de2671
--- /dev/null
+++ b/cli/tests/node_compat/test/parallel/test-module-run-main.js
@@ -0,0 +1,15 @@
+// deno-fmt-ignore-file
+// deno-lint-ignore-file
+
+"use strict";
+
+const Module = require("module");
+const assert = require("assert/strict");
+const path = require("path");
+
+const file = path.join(__dirname, "..", "fixtures", "run-main.js");
+process.argv = [process.argv[0], file];
+Module.runMain();
+
+// The required file via `Module.runMain()` sets this global
+assert.equal(globalThis.foo, 42);
diff --git a/ext/node/polyfills/01_require.js b/ext/node/polyfills/01_require.js
index c73701ba80..a8a70c2fca 100644
--- a/ext/node/polyfills/01_require.js
+++ b/ext/node/polyfills/01_require.js
@@ -1108,6 +1108,11 @@ Module.syncBuiltinESMExports = function syncBuiltinESMExports() {
   throw new Error("not implemented");
 };
 
+// Mostly used by tools like ts-node.
+Module.runMain = function () {
+  Module._load(process.argv[1], null, true);
+};
+
 Module.Module = Module;
 
 nativeModuleExports.module = Module;