diff --git a/ext/ffi/lib.rs b/ext/ffi/lib.rs
index a5fc6b756a..ca02aca5bb 100644
--- a/ext/ffi/lib.rs
+++ b/ext/ffi/lib.rs
@@ -810,12 +810,16 @@ where
               )
             })?
             .get_backing_store();
-          let pointer = &backing_store[byte_offset] as *const _ as *const u8;
+          let pointer = if byte_offset > 0 {
+            &backing_store[byte_offset..] as *const _ as *const u8
+          } else {
+            &backing_store[..] as *const _ as *const u8
+          };
           ffi_args.push(NativeValue { pointer });
         } else if let Ok(value) = v8::Local::<v8::ArrayBuffer>::try_from(value)
         {
           let backing_store = value.get_backing_store();
-          let pointer = &backing_store as *const _ as *const u8;
+          let pointer = &backing_store[..] as *const _ as *const u8;
           ffi_args.push(NativeValue { pointer });
         } else {
           return Err(type_error("Invalid FFI pointer type, expected null, BigInt, ArrayBuffer, or ArrayBufferView"));
@@ -995,13 +999,17 @@ where
               )
             })?
             .get_backing_store();
-          let pointer = &backing_store[byte_offset] as *const _ as *const u8;
+          let pointer = if byte_offset > 0 {
+            &backing_store[byte_offset..] as *const _ as *const u8
+          } else {
+            &backing_store[..] as *const _ as *const u8
+          };
 
           ffi_args.push(NativeValue { pointer });
         } else if let Ok(value) = v8::Local::<v8::ArrayBuffer>::try_from(value)
         {
           let backing_store = value.get_backing_store();
-          let pointer = &backing_store as *const _ as *const u8;
+          let pointer = &backing_store[..] as *const _ as *const u8;
 
           ffi_args.push(NativeValue { pointer });
         } else {
@@ -1367,11 +1375,15 @@ unsafe fn do_ffi_callback(
           .buffer(&mut scope)
           .expect("Unable to deserialize result parameter.")
           .get_backing_store();
-        let pointer = &backing_store[byte_offset] as *const _ as *const u8;
+        let pointer = if byte_offset > 0 {
+          &backing_store[byte_offset..] as *const _ as *const u8
+        } else {
+          &backing_store[..] as *const _ as *const u8
+        };
         *(result as *mut *const u8) = pointer;
       } else if let Ok(value) = v8::Local::<v8::ArrayBuffer>::try_from(value) {
         let backing_store = value.get_backing_store();
-        let pointer = &backing_store as *const _ as *const u8;
+        let pointer = &backing_store[..] as *const _ as *const u8;
         *(result as *mut *const u8) = pointer;
       } else if let Ok(value) = v8::Local::<v8::BigInt>::try_from(value) {
         *(result as *mut u64) = value.u64_value().0;
diff --git a/test_ffi/tests/integration_tests.rs b/test_ffi/tests/integration_tests.rs
index 35f37aa144..5ca430f43d 100644
--- a/test_ffi/tests/integration_tests.rs
+++ b/test_ffi/tests/integration_tests.rs
@@ -56,6 +56,8 @@ fn basic() {
     false\n\
     true\n\
     false\n\
+    false\n\
+    false\n\
     579\n\
     true\n\
     579\n\
diff --git a/test_ffi/tests/test.js b/test_ffi/tests/test.js
index 03c166a7c4..af2f522a68 100644
--- a/test_ffi/tests/test.js
+++ b/test_ffi/tests/test.js
@@ -214,6 +214,10 @@ console.log(stringPtrview.getCString(11));
 console.log(Boolean(dylib.symbols.is_null_ptr(ptr0)));
 console.log(Boolean(dylib.symbols.is_null_ptr(null)));
 console.log(Boolean(dylib.symbols.is_null_ptr(Deno.UnsafePointer.of(into))));
+const emptyBuffer = new BigUint64Array(0);
+console.log(Boolean(dylib.symbols.is_null_ptr(emptyBuffer)));
+const emptySlice = into.subarray(6);
+console.log(Boolean(dylib.symbols.is_null_ptr(emptySlice)));
 
 const addU32Ptr = dylib.symbols.get_add_u32_ptr();
 const addU32 = new Deno.UnsafeFnPointer(addU32Ptr, {