diff --git a/cli/tests/integration/test_tests.rs b/cli/tests/integration/test_tests.rs
index 3f23efca22..07c1b6c7d7 100644
--- a/cli/tests/integration/test_tests.rs
+++ b/cli/tests/integration/test_tests.rs
@@ -151,6 +151,11 @@ itest!(ops_sanitizer_unstable {
   output: "test/ops_sanitizer_unstable.out",
 });
 
+itest!(ops_sanitizer_timeout_failure {
+  args: "test test/ops_sanitizer_timeout_failure.ts",
+  output: "test/ops_sanitizer_timeout_failure.out",
+});
+
 itest!(exit_sanitizer {
   args: "test test/exit_sanitizer.ts",
   output: "test/exit_sanitizer.out",
diff --git a/cli/tests/testdata/test/ops_sanitizer_timeout_failure.out b/cli/tests/testdata/test/ops_sanitizer_timeout_failure.out
new file mode 100644
index 0000000000..81a1af63b8
--- /dev/null
+++ b/cli/tests/testdata/test/ops_sanitizer_timeout_failure.out
@@ -0,0 +1,6 @@
+Check [WILDCARD]/testdata/test/ops_sanitizer_timeout_failure.ts
+running 1 test from [WILDCARD]/testdata/test/ops_sanitizer_timeout_failure.ts
+test wait ... ok ([WILDCARD])
+
+test result: ok. 1 passed; 0 failed; 0 ignored; 0 measured; 0 filtered out ([WILDCARD])
+
diff --git a/cli/tests/testdata/test/ops_sanitizer_timeout_failure.ts b/cli/tests/testdata/test/ops_sanitizer_timeout_failure.ts
new file mode 100644
index 0000000000..d40a5a2581
--- /dev/null
+++ b/cli/tests/testdata/test/ops_sanitizer_timeout_failure.ts
@@ -0,0 +1,22 @@
+let intervalHandle: number;
+let firstIntervalPromise: Promise<void>;
+
+addEventListener("load", () => {
+  firstIntervalPromise = new Promise((resolve) => {
+    let firstIntervalCalled = false;
+    intervalHandle = setInterval(() => {
+      if (!firstIntervalCalled) {
+        resolve();
+        firstIntervalCalled = true;
+      }
+    }, 5);
+  });
+});
+
+addEventListener("unload", () => {
+  clearInterval(intervalHandle);
+});
+
+Deno.test("wait", async function () {
+  await firstIntervalPromise;
+});
diff --git a/runtime/js/40_testing.js b/runtime/js/40_testing.js
index 053afc5dab..e8b07d494a 100644
--- a/runtime/js/40_testing.js
+++ b/runtime/js/40_testing.js
@@ -30,6 +30,37 @@
   } = window.__bootstrap.primordials;
   let testStepsEnabled = false;
 
+  let opSanitizerDelayResolve = null;
+
+  // Even if every resource is closed by the end of a test, there can be a delay
+  // until the pending ops have all finished. This function returns a promise
+  // that resolves when it's (probably) fine to run the op sanitizer.
+  //
+  // This is implemented by adding a macrotask callback that runs after the
+  // timer macrotasks, so we can guarantee that a currently running interval
+  // will have an associated op. An additional `setTimeout` of 0 is needed
+  // before that, though, in order to give time for worker message ops to finish
+  // (since timeouts of 0 don't queue tasks in the timer queue immediately).
+  function opSanitizerDelay() {
+    return new Promise((resolve, reject) => {
+      setTimeout(() => {
+        if (opSanitizerDelayResolve !== null) {
+          reject(new Error("There is an op sanitizer delay already."));
+        } else {
+          opSanitizerDelayResolve = resolve;
+        }
+      }, 0);
+    });
+  }
+
+  function handleOpSanitizerDelayMacrotask() {
+    if (opSanitizerDelayResolve !== null) {
+      opSanitizerDelayResolve();
+      opSanitizerDelayResolve = null;
+    }
+    return true;
+  }
+
   // Wrap test function in additional assertion that makes sure
   // the test case does not leak async "ops" - ie. number of async
   // completed ops after the test is the same as number of dispatched
@@ -45,7 +76,7 @@
         // Defer until next event loop turn - that way timeouts and intervals
         // cleared can actually be removed from resource table, otherwise
         // false positives may occur (https://github.com/denoland/deno/issues/4591)
-        await new Promise((resolve) => setTimeout(resolve, 0));
+        await opSanitizerDelay();
       }
 
       if (step.shouldSkipSanitizers) {
@@ -466,6 +497,8 @@ finishing test case.`;
     filter = null,
     shuffle = null,
   } = {}) {
+    core.setMacrotaskCallback(handleOpSanitizerDelayMacrotask);
+
     const origin = getTestOrigin();
     const originalConsole = globalThis.console;