diff --git a/cli/ops/io.rs b/cli/ops/io.rs
index 785bb42b7a..c35e0d4b67 100644
--- a/cli/ops/io.rs
+++ b/cli/ops/io.rs
@@ -37,36 +37,48 @@ lazy_static! {
   /// resource table is dropped storing reference to that handle, the handle
   /// itself won't be closed (so Deno.core.print) will still work.
   // TODO(ry) It should be possible to close stdout.
-  static ref STDIN_HANDLE: std::fs::File = {
+  static ref STDIN_HANDLE: Option<std::fs::File> = {
     #[cfg(not(windows))]
-    let stdin = unsafe { std::fs::File::from_raw_fd(0) };
+    let stdin = unsafe { Some(std::fs::File::from_raw_fd(0)) };
     #[cfg(windows)]
     let stdin = unsafe {
-      std::fs::File::from_raw_handle(winapi::um::processenv::GetStdHandle(
+      let handle = winapi::um::processenv::GetStdHandle(
         winapi::um::winbase::STD_INPUT_HANDLE,
-      ))
+      );
+      if handle.is_null() {
+        return None;
+      }
+      Some(std::fs::File::from_raw_handle(handle))
     };
     stdin
   };
-  static ref STDOUT_HANDLE: std::fs::File = {
+  static ref STDOUT_HANDLE: Option<std::fs::File> = {
     #[cfg(not(windows))]
-    let stdout = unsafe { std::fs::File::from_raw_fd(1) };
+    let stdout = unsafe { Some(std::fs::File::from_raw_fd(1)) };
     #[cfg(windows)]
     let stdout = unsafe {
-      std::fs::File::from_raw_handle(winapi::um::processenv::GetStdHandle(
+      let handle = winapi::um::processenv::GetStdHandle(
         winapi::um::winbase::STD_OUTPUT_HANDLE,
-      ))
+      );
+      if handle.is_null() {
+        return None;
+      }
+      Some(std::fs::File::from_raw_handle(handle))
     };
     stdout
   };
-  static ref STDERR_HANDLE: std::fs::File = {
+  static ref STDERR_HANDLE: Option<std::fs::File> = {
     #[cfg(not(windows))]
-    let stderr = unsafe { std::fs::File::from_raw_fd(2) };
+    let stderr = unsafe { Some(std::fs::File::from_raw_fd(2)) };
     #[cfg(windows)]
     let stderr = unsafe {
-      std::fs::File::from_raw_handle(winapi::um::processenv::GetStdHandle(
+      let handle = winapi::um::processenv::GetStdHandle(
         winapi::um::winbase::STD_ERROR_HANDLE,
-      ))
+      );
+      if handle.is_null() {
+        return None;
+      }
+      Some(std::fs::File::from_raw_handle(handle))
     };
     stderr
   };
@@ -78,26 +90,31 @@ pub fn init(i: &mut CoreIsolate, s: &State) {
 }
 
 pub fn get_stdio() -> (
-  StreamResourceHolder,
-  StreamResourceHolder,
-  StreamResourceHolder,
+  Option<StreamResourceHolder>,
+  Option<StreamResourceHolder>,
+  Option<StreamResourceHolder>,
 ) {
-  let stdin = StreamResourceHolder::new(StreamResource::FsFile(Some({
-    let stdin = STDIN_HANDLE.try_clone().unwrap();
-    (tokio::fs::File::from_std(stdin), FileMetadata::default())
-  })));
-  let stdout = StreamResourceHolder::new(StreamResource::FsFile(Some({
-    let stdout = STDOUT_HANDLE.try_clone().unwrap();
-    (tokio::fs::File::from_std(stdout), FileMetadata::default())
-  })));
-  let stderr = StreamResourceHolder::new(StreamResource::FsFile(Some({
-    let stderr = STDERR_HANDLE.try_clone().unwrap();
-    (tokio::fs::File::from_std(stderr), FileMetadata::default())
-  })));
+  let stdin = get_stdio_stream(&STDIN_HANDLE);
+  let stdout = get_stdio_stream(&STDOUT_HANDLE);
+  let stderr = get_stdio_stream(&STDERR_HANDLE);
 
   (stdin, stdout, stderr)
 }
 
+fn get_stdio_stream(
+  handle: &Option<std::fs::File>,
+) -> Option<StreamResourceHolder> {
+  match handle {
+    None => None,
+    Some(file_handle) => match file_handle.try_clone() {
+      Ok(clone) => Some(StreamResourceHolder::new(StreamResource::FsFile(
+        Some((tokio::fs::File::from_std(clone), FileMetadata::default())),
+      ))),
+      Err(_e) => None,
+    },
+  }
+}
+
 fn no_buffer_specified() -> OpError {
   OpError::type_error("no buffer specified".to_string())
 }
diff --git a/cli/ops/worker_host.rs b/cli/ops/worker_host.rs
index 950797352e..e3571f7133 100644
--- a/cli/ops/worker_host.rs
+++ b/cli/ops/worker_host.rs
@@ -58,9 +58,15 @@ fn create_web_worker(
     let state = state_rc.borrow();
     let mut resource_table = state.resource_table.borrow_mut();
     let (stdin, stdout, stderr) = get_stdio();
-    resource_table.add("stdin", Box::new(stdin));
-    resource_table.add("stdout", Box::new(stdout));
-    resource_table.add("stderr", Box::new(stderr));
+    if let Some(stream) = stdin {
+      resource_table.add("stdin", Box::new(stream));
+    }
+    if let Some(stream) = stdout {
+      resource_table.add("stdout", Box::new(stream));
+    }
+    if let Some(stream) = stderr {
+      resource_table.add("stderr", Box::new(stream));
+    }
   }
 
   // Instead of using name for log we use `worker-${id}` because
diff --git a/cli/tests/DenoWinRunner.cs b/cli/tests/DenoWinRunner.cs
new file mode 100644
index 0000000000..7879d146dd
--- /dev/null
+++ b/cli/tests/DenoWinRunner.cs
@@ -0,0 +1,127 @@
+using System;
+using System.ComponentModel;
+using System.Diagnostics;
+using System.IO;
+using System.Runtime.InteropServices;
+using System.Threading.Tasks;
+
+[Flags]
+public enum DenoConstraints : int
+{
+    None = 0,
+    NoStdin = 1,
+    NoStdout = 2,
+    NoStderr = 4
+}
+
+public class DenoWinRunner
+{
+    private const int STD_INPUT_HANDLE = -10;
+    private const int STD_OUTPUT_HANDLE = -11;
+    private const int STD_ERROR_HANDLE = -12;
+
+    private const int FILE_NOT_FOUND = 2;
+    private const int WAIT_TIMEOUT = 258;
+
+    [DllImport("kernel32.dll")]
+    private static extern void SetStdHandle(int nStdHandle, IntPtr handle);
+
+    /// <summary>
+    /// Runs Deno.exe under the specified constraints
+    /// </summary>
+    /// <param name="pathToDenoExe">Path to the Deno.exe file. Can be absolute or relative</param>
+    /// <param name="pathToTestScript">Path to the script file Deno should run.</param>
+    /// <param name="constraints">The contrainsts to apply to the Deno process</param>
+    /// <param name="timeoutMilliseconds">How long to wait for the Deno process to exit</param>
+    /// <returns>The deno.exe exit code, or an exit code provided by the test runner</returns>
+    public static int RunDenoScript(string pathToDenoExe, string pathToTestScript, DenoConstraints constraints, uint timeoutMilliseconds = 1000)
+    {
+        try
+        {
+            if (!File.Exists(pathToDenoExe))
+            {
+                Console.Error.WriteLine("Cannot find Deno.exe at " + pathToDenoExe);
+                return FILE_NOT_FOUND;
+            }
+
+            if (!File.Exists(pathToTestScript))
+            {
+                Console.Error.WriteLine("Cannot find test script at " + pathToTestScript);
+                return FILE_NOT_FOUND;
+            }
+
+            ProcessStartInfo startInfo = new ProcessStartInfo(pathToDenoExe)
+            {
+                ErrorDialog = false,
+                UseShellExecute = false,
+                Arguments = @"run -A " + pathToTestScript,
+                RedirectStandardInput = !constraints.HasFlag(DenoConstraints.NoStdin),
+                RedirectStandardOutput = !constraints.HasFlag(DenoConstraints.NoStdout),
+                RedirectStandardError = !constraints.HasFlag(DenoConstraints.NoStderr)
+            };
+
+            startInfo.Environment.Add("RUST_BACKTRACE", "1");
+
+            if (constraints.HasFlag(DenoConstraints.NoStdin))
+            {
+                SetStdHandle(STD_INPUT_HANDLE, (IntPtr)null);
+            }
+            
+            if (constraints.HasFlag(DenoConstraints.NoStdout))
+            {
+                SetStdHandle(STD_OUTPUT_HANDLE, (IntPtr)null);
+            }
+
+            if (constraints.HasFlag(DenoConstraints.NoStderr))
+            {
+                SetStdHandle(STD_ERROR_HANDLE, (IntPtr)null);
+            }
+            
+            Process process = new Process { StartInfo = startInfo };
+            process.Start();
+
+            Task<string> stdErrTask = startInfo.RedirectStandardError ? 
+                process.StandardError.ReadToEndAsync() : Task.FromResult<string>(null);
+            Task<string> stdOutTask = startInfo.RedirectStandardOutput ? 
+                process.StandardOutput.ReadToEndAsync() : Task.FromResult<string>(null);
+
+            if (!process.WaitForExit((int)timeoutMilliseconds))
+            {
+                Console.Error.WriteLine("Timed out waiting for Deno process to exit");
+                try
+                {
+                    process.Kill();
+                }
+                catch
+                {
+                    // Kill might fail, either because the process already exited or due to some other error
+                    Console.Error.WriteLine("Failure killing the Deno process - possible Zombie Deno.exe process");
+                }
+                return WAIT_TIMEOUT;
+            }
+
+            // If the Deno process wrote to STDERR - append it to our STDERR
+            if (!constraints.HasFlag(DenoConstraints.NoStderr))
+            {
+                string error = stdErrTask.Result;
+                if (!string.IsNullOrWhiteSpace(error))
+                {
+                    Console.Error.WriteLine(error);
+                }
+            }
+
+            return process.ExitCode;
+
+        }
+        catch (Win32Exception ex)
+        {
+            Console.Error.WriteLine("Win32Exception: code = " + ex.ErrorCode + ", message: " + ex.Message);
+            return ex.NativeErrorCode;
+        }
+        catch (Exception ex)
+        {
+            Console.Error.WriteLine("Exception: message: " + ex.Message);
+            return -1;
+        }
+    }
+}
\ No newline at end of file
diff --git a/cli/tests/DenoWinRunner.ps1 b/cli/tests/DenoWinRunner.ps1
new file mode 100644
index 0000000000..203b5d36ca
--- /dev/null
+++ b/cli/tests/DenoWinRunner.ps1
@@ -0,0 +1,10 @@
+$Source = [IO.File]::ReadAllText("$PSScriptRoot\DenoWinRunner.cs")
+$denoExePath = $args[0]
+$scriptPath = $args[1]
+$constraints = $args[2]
+$timeout = 5000;
+Add-Type -TypeDefinition $Source -Language CSharp
+Write-Output("Running Deno script: " + $args[1])
+$code = [DenoWinRunner]::RunDenoScript($denoExePath, $scriptPath, $constraints, $timeout)
+Write-Output("Deno.exe or the test wrapper has exited with code: $code")
+exit $code
diff --git a/cli/tests/integration_tests.rs b/cli/tests/integration_tests.rs
index 87a6f9d63c..2ec25d0d05 100644
--- a/cli/tests/integration_tests.rs
+++ b/cli/tests/integration_tests.rs
@@ -3116,3 +3116,62 @@ fn set_raw_should_not_panic_on_no_tty() {
   let stderr = std::str::from_utf8(&output.stderr).unwrap().trim();
   assert!(stderr.contains("BadResource"));
 }
+
+#[cfg(windows)]
+enum WinProcConstraints {
+  NoStdIn,
+  NoStdOut,
+  NoStdErr,
+}
+
+#[cfg(windows)]
+fn run_deno_script_constrained(
+  script_path: std::path::PathBuf,
+  constraints: WinProcConstraints,
+) -> Result<(), i64> {
+  let file_path = "cli/tests/DenoWinRunner.ps1";
+  let constraints = match constraints {
+    WinProcConstraints::NoStdIn => "1",
+    WinProcConstraints::NoStdOut => "2",
+    WinProcConstraints::NoStdErr => "4",
+  };
+  let deno_exe_path = util::deno_exe_path()
+    .into_os_string()
+    .into_string()
+    .unwrap();
+
+  let deno_script_path = script_path.into_os_string().into_string().unwrap();
+
+  let args = vec![&deno_exe_path[..], &deno_script_path[..], constraints];
+  util::run_powershell_script_file(file_path, args)
+}
+
+#[cfg(windows)]
+#[test]
+fn should_not_panic_on_no_stdin() {
+  let output = run_deno_script_constrained(
+    util::tests_path().join("echo.ts"),
+    WinProcConstraints::NoStdIn,
+  );
+  output.unwrap();
+}
+
+#[cfg(windows)]
+#[test]
+fn should_not_panic_on_no_stdout() {
+  let output = run_deno_script_constrained(
+    util::tests_path().join("echo.ts"),
+    WinProcConstraints::NoStdOut,
+  );
+  output.unwrap();
+}
+
+#[cfg(windows)]
+#[test]
+fn should_not_panic_on_no_stderr() {
+  let output = run_deno_script_constrained(
+    util::tests_path().join("echo.ts"),
+    WinProcConstraints::NoStdErr,
+  );
+  output.unwrap();
+}
diff --git a/cli/worker.rs b/cli/worker.rs
index 4ac1ee6a62..08367da91a 100644
--- a/cli/worker.rs
+++ b/cli/worker.rs
@@ -300,9 +300,15 @@ impl MainWorker {
       let state_rc = CoreIsolate::state(&worker.isolate);
       let state = state_rc.borrow();
       let mut t = state.resource_table.borrow_mut();
-      t.add("stdin", Box::new(stdin));
-      t.add("stdout", Box::new(stdout));
-      t.add("stderr", Box::new(stderr));
+      if let Some(stream) = stdin {
+        t.add("stdin", Box::new(stream));
+      }
+      if let Some(stream) = stdout {
+        t.add("stdout", Box::new(stream));
+      }
+      if let Some(stream) = stderr {
+        t.add("stderr", Box::new(stream));
+      }
     }
     worker.execute("bootstrap.mainRuntime()")?;
     Ok(worker)
diff --git a/test_util/src/lib.rs b/test_util/src/lib.rs
index fb7b8f88e0..73a1df043d 100644
--- a/test_util/src/lib.rs
+++ b/test_util/src/lib.rs
@@ -591,6 +591,37 @@ pub fn run_python_script(script: &str) {
   }
 }
 
+pub fn run_powershell_script_file(
+  script_file_path: &str,
+  args: Vec<&str>,
+) -> Result<(), i64> {
+  let deno_dir = new_deno_dir();
+  let mut command = Command::new("powershell.exe");
+
+  command
+    .env("DENO_DIR", deno_dir.path())
+    .current_dir(root_path())
+    .arg("-file")
+    .arg(script_file_path);
+
+  for arg in args {
+    command.arg(arg);
+  }
+
+  let output = command.output().expect("failed to spawn script");
+  let stdout = String::from_utf8(output.stdout).unwrap();
+  let stderr = String::from_utf8(output.stderr).unwrap();
+  println!("{}", stdout);
+  if !output.status.success() {
+    panic!(
+      "{} executed with failing error code\n{}{}",
+      script_file_path, stdout, stderr
+    );
+  }
+
+  Ok(())
+}
+
 #[derive(Debug, Default)]
 pub struct CheckOutputIntegrationTest {
   pub args: &'static str,