diff --git a/ext/console/01_console.js b/ext/console/01_console.js
index 017e6cb772..15c5c837b1 100644
--- a/ext/console/01_console.js
+++ b/ext/console/01_console.js
@@ -260,6 +260,7 @@ const colors = {
 
 function defineColorAlias(target, alias) {
   ObjectDefineProperty(colors, alias, {
+    __proto__: null,
     get() {
       return this[target];
     },
@@ -3447,7 +3448,10 @@ function inspect(
 function createFilteredInspectProxy({ object, keys, evaluate }) {
   const obj = class {};
   if (object.constructor?.name) {
-    ObjectDefineProperty(obj, "name", { value: object.constructor.name });
+    ObjectDefineProperty(obj, "name", {
+      __proto__: null,
+      value: object.constructor.name,
+    });
   }
 
   return new Proxy(new obj(), {
diff --git a/ext/fetch/22_body.js b/ext/fetch/22_body.js
index a8f5deac9c..61a06b4afd 100644
--- a/ext/fetch/22_body.js
+++ b/ext/fetch/22_body.js
@@ -263,6 +263,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
   /** @type {PropertyDescriptorMap} */
   const mixin = {
     body: {
+      __proto__: null,
       /**
        * @returns {ReadableStream<Uint8Array> | null}
        */
@@ -278,6 +279,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     bodyUsed: {
+      __proto__: null,
       /**
        * @returns {boolean}
        */
@@ -292,6 +294,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     arrayBuffer: {
+      __proto__: null,
       /** @returns {Promise<ArrayBuffer>} */
       value: function arrayBuffer() {
         return consumeBody(this, "ArrayBuffer");
@@ -301,6 +304,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     blob: {
+      __proto__: null,
       /** @returns {Promise<Blob>} */
       value: function blob() {
         return consumeBody(this, "Blob");
@@ -310,6 +314,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     bytes: {
+      __proto__: null,
       /** @returns {Promise<Uint8Array>} */
       value: function bytes() {
         return consumeBody(this, "bytes");
@@ -319,6 +324,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     formData: {
+      __proto__: null,
       /** @returns {Promise<FormData>} */
       value: function formData() {
         return consumeBody(this, "FormData");
@@ -328,6 +334,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     json: {
+      __proto__: null,
       /** @returns {Promise<any>} */
       value: function json() {
         return consumeBody(this, "JSON");
@@ -337,6 +344,7 @@ function mixinBody(prototype, bodySymbol, mimeTypeSymbol) {
       enumerable: true,
     },
     text: {
+      __proto__: null,
       /** @returns {Promise<string>} */
       value: function text() {
         return consumeBody(this, "text");
diff --git a/ext/fetch/22_http_client.js b/ext/fetch/22_http_client.js
index 061a3dda89..6a1243ee0b 100644
--- a/ext/fetch/22_http_client.js
+++ b/ext/fetch/22_http_client.js
@@ -42,6 +42,7 @@ class HttpClient {
    */
   constructor(rid) {
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
diff --git a/ext/fetch/23_response.js b/ext/fetch/23_response.js
index 7dad8c0472..ff4ad5facd 100644
--- a/ext/fetch/23_response.js
+++ b/ext/fetch/23_response.js
@@ -432,9 +432,9 @@ class Response {
 
 webidl.configureInterface(Response);
 ObjectDefineProperties(Response, {
-  json: { enumerable: true },
-  redirect: { enumerable: true },
-  error: { enumerable: true },
+  json: { __proto__: null, enumerable: true },
+  redirect: { __proto__: null, enumerable: true },
+  error: { __proto__: null, enumerable: true },
 });
 const ResponsePrototype = Response.prototype;
 mixinBody(ResponsePrototype, _body, _mimeType);
diff --git a/ext/fetch/27_eventsource.js b/ext/fetch/27_eventsource.js
index 685eb47c2d..aadbb5fe71 100644
--- a/ext/fetch/27_eventsource.js
+++ b/ext/fetch/27_eventsource.js
@@ -355,12 +355,15 @@ const EventSourcePrototype = EventSource.prototype;
 
 ObjectDefineProperties(EventSource, {
   CONNECTING: {
+    __proto__: null,
     value: 0,
   },
   OPEN: {
+    __proto__: null,
     value: 1,
   },
   CLOSED: {
+    __proto__: null,
     value: 2,
   },
 });
diff --git a/ext/ffi/00_ffi.js b/ext/ffi/00_ffi.js
index 1475f8d3fc..d3b07dc373 100644
--- a/ext/ffi/00_ffi.js
+++ b/ext/ffi/00_ffi.js
@@ -484,10 +484,11 @@ class DynamicLibrary {
           this.symbols,
           symbol,
           {
+            __proto__: null,
             configurable: false,
             enumerable: true,
-            value,
             writable: false,
+            value,
           },
         );
         continue;
@@ -504,8 +505,10 @@ class DynamicLibrary {
           this.symbols,
           symbol,
           {
+            __proto__: null,
             configurable: false,
             enumerable: true,
+            writable: false,
             value: (...parameters) => {
               if (isStructResult) {
                 const buffer = new Uint8Array(structSize);
@@ -527,7 +530,6 @@ class DynamicLibrary {
                 );
               }
             },
-            writable: false,
           },
         );
       }
diff --git a/ext/fs/30_fs.js b/ext/fs/30_fs.js
index 28d8365f0f..b284b7fce7 100644
--- a/ext/fs/30_fs.js
+++ b/ext/fs/30_fs.js
@@ -585,6 +585,7 @@ class FsFile {
 
   constructor(rid, symbol) {
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
diff --git a/ext/net/01_net.js b/ext/net/01_net.js
index 87bbcd476f..12a0a6bf28 100644
--- a/ext/net/01_net.js
+++ b/ext/net/01_net.js
@@ -103,11 +103,13 @@ class Conn {
   constructor(rid, remoteAddr, localAddr) {
     if (internals.future) {
       ObjectDefineProperty(this, "rid", {
+        __proto__: null,
         enumerable: false,
         value: undefined,
       });
     }
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
@@ -214,6 +216,7 @@ class TcpConn extends Conn {
   constructor(rid, remoteAddr, localAddr) {
     super(rid, remoteAddr, localAddr);
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
@@ -244,6 +247,7 @@ class UnixConn extends Conn {
   constructor(rid, remoteAddr, localAddr) {
     super(rid, remoteAddr, localAddr);
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
@@ -269,11 +273,13 @@ class Listener {
   constructor(rid, addr) {
     if (internals.future) {
       ObjectDefineProperty(this, "rid", {
+        __proto__: null,
         enumerable: false,
         value: undefined,
       });
     }
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
diff --git a/ext/net/02_tls.js b/ext/net/02_tls.js
index f6197e1599..0ea5e8ca29 100644
--- a/ext/net/02_tls.js
+++ b/ext/net/02_tls.js
@@ -30,6 +30,7 @@ class TlsConn extends Conn {
   constructor(rid, remoteAddr, localAddr) {
     super(rid, remoteAddr, localAddr);
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
@@ -110,6 +111,7 @@ class TlsListener extends Listener {
   constructor(rid, addr) {
     super(rid, addr);
     ObjectDefineProperty(this, internalRidSymbol, {
+      __proto__: null,
       enumerable: false,
       value: rid,
     });
diff --git a/ext/node/benchmarks/child_process_ipc.mjs b/ext/node/benchmarks/child_process_ipc.mjs
index 7a5c992bd3..fa671d76f7 100644
--- a/ext/node/benchmarks/child_process_ipc.mjs
+++ b/ext/node/benchmarks/child_process_ipc.mjs
@@ -29,6 +29,7 @@ if (process.env.CHILD) {
       const start = performance.now();
 
       const options = {
+        __proto__: null,
         "stdio": ["inherit", "inherit", "inherit", "ipc"],
         "env": { "CHILD": len.toString() },
       };
diff --git a/ext/node/polyfills/_brotli.js b/ext/node/polyfills/_brotli.js
index 0dcb58e047..ebd0351561 100644
--- a/ext/node/polyfills/_brotli.js
+++ b/ext/node/polyfills/_brotli.js
@@ -60,7 +60,7 @@ export class BrotliDecompress extends Transform {
   #context;
 
   // TODO(littledivy): use `options` argument
-  constructor(_options = {}) {
+  constructor(_options = { __proto__: null }) {
     super({
       // TODO(littledivy): use `encoding` argument
       transform(chunk, _encoding, callback) {
@@ -91,7 +91,7 @@ export class BrotliDecompress extends Transform {
 export class BrotliCompress extends Transform {
   #context;
 
-  constructor(options = {}) {
+  constructor(options = { __proto__: null }) {
     super({
       // TODO(littledivy): use `encoding` argument
       transform(chunk, _encoding, callback) {
diff --git a/ext/node/polyfills/_process/streams.mjs b/ext/node/polyfills/_process/streams.mjs
index fa24bd1555..19c1c9c182 100644
--- a/ext/node/polyfills/_process/streams.mjs
+++ b/ext/node/polyfills/_process/streams.mjs
@@ -65,22 +65,26 @@ export function createWritableStdioStream(writer, name, warmup = false) {
   stream.once("close", () => writer?.close());
   ObjectDefineProperties(stream, {
     columns: {
+      __proto__: null,
       enumerable: true,
       configurable: true,
       get: () =>
         writer?.isTerminal() ? Deno.consoleSize?.().columns : undefined,
     },
     rows: {
+      __proto__: null,
       enumerable: true,
       configurable: true,
       get: () => writer?.isTerminal() ? Deno.consoleSize?.().rows : undefined,
     },
     isTTY: {
+      __proto__: null,
       enumerable: true,
       configurable: true,
       get: () => writer?.isTerminal(),
     },
     getWindowSize: {
+      __proto__: null,
       enumerable: true,
       configurable: true,
       value: () =>
@@ -203,6 +207,7 @@ export const initStdin = (warmup = false) => {
   stdin.on("close", () => io.stdin?.close());
   stdin.fd = io.stdin ? io.STDIN_RID : -1;
   ObjectDefineProperty(stdin, "isTTY", {
+    __proto__: null,
     enumerable: true,
     configurable: true,
     get() {
@@ -216,6 +221,7 @@ export const initStdin = (warmup = false) => {
     return stdin;
   };
   ObjectDefineProperty(stdin, "isRaw", {
+    __proto__: null,
     enumerable: true,
     configurable: true,
     get() {
diff --git a/ext/node/polyfills/_util/async.ts b/ext/node/polyfills/_util/async.ts
index cc116412c1..0cacccacc7 100644
--- a/ext/node/polyfills/_util/async.ts
+++ b/ext/node/polyfills/_util/async.ts
@@ -13,7 +13,7 @@ import { clearTimeout, setTimeout } from "ext:deno_web/02_timers.js";
 /** Resolve a Promise after a given amount of milliseconds. */
 export function delay(
   ms: number,
-  options: { signal?: AbortSignal } = {},
+  options: { signal?: AbortSignal } = { __proto__: null },
 ): Promise<void> {
   const { signal } = options;
   if (signal?.aborted) {
diff --git a/ext/node/polyfills/_util/std_testing_diff.ts b/ext/node/polyfills/_util/std_testing_diff.ts
index 74e396b0c5..5155fd242c 100644
--- a/ext/node/polyfills/_util/std_testing_diff.ts
+++ b/ext/node/polyfills/_util/std_testing_diff.ts
@@ -325,7 +325,10 @@ export function diffstr(A: string, B: string) {
     );
   }
 
-  function tokenize(string: string, { wordDiff = false } = {}): string[] {
+  function tokenize(
+    string: string,
+    { wordDiff = false } = { __proto__: null },
+  ): string[] {
     if (wordDiff) {
       // Split string on whitespace symbols
       const tokens = StringPrototypeSplit(string, WHITESPACE_SYMBOL_PATTERN);
@@ -450,7 +453,7 @@ export function diffstr(A: string, B: string) {
  */
 function createColor(
   diffType: DiffType,
-  { background = false } = {},
+  { background = false } = { __proto__: null },
 ): (s: string) => string {
   // TODO(@littledivy): Remove this when we can detect
   // true color terminals.
@@ -484,7 +487,7 @@ function createSign(diffType: DiffType): string {
 
 export function buildMessage(
   diffResult: ReadonlyArray<DiffResult<string>>,
-  { stringDiff = false } = {},
+  { stringDiff = false } = { __proto__: null },
 ): string[] {
   const messages: string[] = [], diffMessages: string[] = [];
   ArrayPrototypePush(messages, "");
diff --git a/ext/node/polyfills/string_decoder.ts b/ext/node/polyfills/string_decoder.ts
index 4a49c2e3e6..b4a422e4b6 100644
--- a/ext/node/polyfills/string_decoder.ts
+++ b/ext/node/polyfills/string_decoder.ts
@@ -403,6 +403,7 @@ StringDecoder.prototype.text = function text(
 
 ObjectDefineProperties(StringDecoder.prototype, {
   lastNeed: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get(this: StringDecoder): number {
@@ -410,6 +411,7 @@ ObjectDefineProperties(StringDecoder.prototype, {
     },
   },
   lastTotal: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get(this: StringDecoder): number {
diff --git a/ext/node/polyfills/timers.ts b/ext/node/polyfills/timers.ts
index b96f448da4..613b87427c 100644
--- a/ext/node/polyfills/timers.ts
+++ b/ext/node/polyfills/timers.ts
@@ -33,6 +33,7 @@ export function setTimeout(
 }
 
 ObjectDefineProperty(setTimeout, promisify.custom, {
+  __proto__: null,
   value: (timeout: number, ...args: unknown[]) => {
     return new Promise((cb) =>
       setTimeout(cb, timeout, ...new SafeArrayIterator(args))
diff --git a/ext/node/polyfills/util.ts b/ext/node/polyfills/util.ts
index c94d0f14b5..586fae17e9 100644
--- a/ext/node/polyfills/util.ts
+++ b/ext/node/polyfills/util.ts
@@ -177,6 +177,7 @@ export function inherits<T, U>(
     );
   }
   ObjectDefineProperty(ctor, "super_", {
+    __proto__: null,
     value: superCtor,
     writable: true,
     configurable: true,
diff --git a/ext/node/polyfills/vm.js b/ext/node/polyfills/vm.js
index bc1a250456..eb9a0375d0 100644
--- a/ext/node/polyfills/vm.js
+++ b/ext/node/polyfills/vm.js
@@ -34,7 +34,7 @@ const kParsingContext = Symbol("script parsing context");
 export class Script {
   #inner;
 
-  constructor(code, options = {}) {
+  constructor(code, options = { __proto__: null }) {
     code = `${code}`;
     if (typeof options === "string") {
       options = { filename: options };
@@ -80,7 +80,7 @@ export class Script {
       : undefined;
   }
 
-  #runInContext(contextifiedObject, options = {}) {
+  #runInContext(contextifiedObject, options = { __proto__: null }) {
     validateObject(options, "options");
 
     let timeout = options.timeout;
@@ -181,7 +181,10 @@ function getContextOptions(options) {
 }
 
 let defaultContextNameIndex = 1;
-export function createContext(contextObject = {}, options = {}) {
+export function createContext(
+  contextObject = {},
+  options = { __proto__: null },
+) {
   if (isContext(contextObject)) {
     return contextObject;
   }
@@ -276,7 +279,7 @@ export function isContext(object) {
   return op_vm_is_context(object);
 }
 
-export function compileFunction(code, params, options = {}) {
+export function compileFunction(code, params, options = { __proto__: null }) {
   validateString(code, "code");
   if (params !== undefined) {
     validateStringArray(params, "params");
diff --git a/ext/node/polyfills/worker_threads.ts b/ext/node/polyfills/worker_threads.ts
index 24bcbe057b..5ff4446f73 100644
--- a/ext/node/polyfills/worker_threads.ts
+++ b/ext/node/polyfills/worker_threads.ts
@@ -267,7 +267,7 @@ class NodeWorker extends EventEmitter {
     }
   };
 
-  postMessage(message, transferOrOptions = {}) {
+  postMessage(message, transferOrOptions = { __proto__: null }) {
     const prefix = "Failed to execute 'postMessage' on 'MessagePort'";
     webidl.requiredArguments(arguments.length, 1, prefix);
     message = webidl.converters.any(message);
diff --git a/ext/web/01_dom_exception.js b/ext/web/01_dom_exception.js
index f49337db59..38e4d088e5 100644
--- a/ext/web/01_dom_exception.js
+++ b/ext/web/01_dom_exception.js
@@ -186,7 +186,7 @@ const entries = ObjectEntries({
 });
 for (let i = 0; i < entries.length; ++i) {
   const { 0: key, 1: value } = entries[i];
-  const desc = { value, enumerable: true };
+  const desc = { __proto__: null, value, enumerable: true };
   ObjectDefineProperty(DOMException, key, desc);
   ObjectDefineProperty(DOMException.prototype, key, desc);
 }
diff --git a/ext/web/02_event.js b/ext/web/02_event.js
index 985578bcc2..f031d0aeda 100644
--- a/ext/web/02_event.js
+++ b/ext/web/02_event.js
@@ -392,6 +392,7 @@ const EventPrototype = Event.prototype;
 // Not spec compliant. The spec defines it as [LegacyUnforgeable]
 // but doing so has a big performance hit
 ReflectDefineProperty(Event.prototype, "isTrusted", {
+  __proto__: null,
   enumerable: true,
   get: isTrusted,
 });
@@ -402,7 +403,10 @@ function defineEnumerableProps(
 ) {
   for (let i = 0; i < props.length; ++i) {
     const prop = props[i];
-    ReflectDefineProperty(Ctor.prototype, prop, { enumerable: true });
+    ReflectDefineProperty(Ctor.prototype, prop, {
+      __proto__: null,
+      enumerable: true,
+    });
   }
 }
 
@@ -1274,6 +1278,7 @@ class CustomEvent extends Event {
 const CustomEventPrototype = CustomEvent.prototype;
 
 ReflectDefineProperty(CustomEvent.prototype, "detail", {
+  __proto__: null,
   enumerable: true,
 });
 
@@ -1417,6 +1422,7 @@ function defineEventHandler(
 ) {
   // HTML specification section 8.1.7.1
   ObjectDefineProperty(emitter, `on${name}`, {
+    __proto__: null,
     get() {
       if (!this[_eventHandlers]) {
         return null;
diff --git a/ext/web/06_streams.js b/ext/web/06_streams.js
index 3da3fe36cb..1dbf769b2b 100644
--- a/ext/web/06_streams.js
+++ b/ext/web/06_streams.js
@@ -5420,6 +5420,7 @@ class ReadableStream {
 // TODO(lucacasonato): should be moved to webidl crate
 ReadableStream.prototype[SymbolAsyncIterator] = ReadableStream.prototype.values;
 ObjectDefineProperty(ReadableStream.prototype, SymbolAsyncIterator, {
+  __proto__: null,
   writable: true,
   enumerable: false,
   configurable: true,
diff --git a/ext/web/10_filereader.js b/ext/web/10_filereader.js
index 05f5771143..05b45202d6 100644
--- a/ext/web/10_filereader.js
+++ b/ext/web/10_filereader.js
@@ -454,36 +454,42 @@ webidl.configureInterface(FileReader);
 const FileReaderPrototype = FileReader.prototype;
 
 ObjectDefineProperty(FileReader, "EMPTY", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
   value: 0,
 });
 ObjectDefineProperty(FileReader, "LOADING", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
   value: 1,
 });
 ObjectDefineProperty(FileReader, "DONE", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
   value: 2,
 });
 ObjectDefineProperty(FileReader.prototype, "EMPTY", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
   value: 0,
 });
 ObjectDefineProperty(FileReader.prototype, "LOADING", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
   value: 1,
 });
 ObjectDefineProperty(FileReader.prototype, "DONE", {
+  __proto__: null,
   writable: false,
   enumerable: true,
   configurable: false,
diff --git a/ext/web/12_location.js b/ext/web/12_location.js
index a819f6a07c..2cda9f719c 100644
--- a/ext/web/12_location.js
+++ b/ext/web/12_location.js
@@ -35,6 +35,7 @@ class Location {
     url.password = "";
     ObjectDefineProperties(this, {
       hash: {
+        __proto__: null,
         get() {
           return url.hash;
         },
@@ -47,6 +48,7 @@ class Location {
         enumerable: true,
       },
       host: {
+        __proto__: null,
         get() {
           return url.host;
         },
@@ -59,6 +61,7 @@ class Location {
         enumerable: true,
       },
       hostname: {
+        __proto__: null,
         get() {
           return url.hostname;
         },
@@ -71,6 +74,7 @@ class Location {
         enumerable: true,
       },
       href: {
+        __proto__: null,
         get() {
           return url.href;
         },
@@ -83,12 +87,14 @@ class Location {
         enumerable: true,
       },
       origin: {
+        __proto__: null,
         get() {
           return url.origin;
         },
         enumerable: true,
       },
       pathname: {
+        __proto__: null,
         get() {
           return url.pathname;
         },
@@ -101,6 +107,7 @@ class Location {
         enumerable: true,
       },
       port: {
+        __proto__: null,
         get() {
           return url.port;
         },
@@ -113,6 +120,7 @@ class Location {
         enumerable: true,
       },
       protocol: {
+        __proto__: null,
         get() {
           return url.protocol;
         },
@@ -125,6 +133,7 @@ class Location {
         enumerable: true,
       },
       search: {
+        __proto__: null,
         get() {
           return url.search;
         },
@@ -137,6 +146,7 @@ class Location {
         enumerable: true,
       },
       ancestorOrigins: {
+        __proto__: null,
         get() {
           // TODO(nayeemrmn): Replace with a `DOMStringList` instance.
           return {
@@ -148,6 +158,7 @@ class Location {
         enumerable: true,
       },
       assign: {
+        __proto__: null,
         value: function assign() {
           throw new DOMException(
             `Cannot call "location.assign()".`,
@@ -157,6 +168,7 @@ class Location {
         enumerable: true,
       },
       reload: {
+        __proto__: null,
         value: function reload() {
           throw new DOMException(
             `Cannot call "location.reload()".`,
@@ -166,6 +178,7 @@ class Location {
         enumerable: true,
       },
       replace: {
+        __proto__: null,
         value: function replace() {
           throw new DOMException(
             `Cannot call "location.replace()".`,
@@ -175,12 +188,14 @@ class Location {
         enumerable: true,
       },
       toString: {
+        __proto__: null,
         value: function toString() {
           return url.href;
         },
         enumerable: true,
       },
       [SymbolFor("Deno.privateCustomInspect")]: {
+        __proto__: null,
         value: function (inspect, inspectOptions) {
           return `${this.constructor.name} ${
             inspect({
@@ -203,6 +218,7 @@ class Location {
 
 ObjectDefineProperties(Location.prototype, {
   [SymbolToStringTag]: {
+    __proto__: null,
     value: "Location",
     configurable: true,
   },
@@ -224,6 +240,7 @@ class WorkerLocation {
 
 ObjectDefineProperties(WorkerLocation.prototype, {
   hash: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -235,6 +252,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   host: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -246,6 +264,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   hostname: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -257,6 +276,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   href: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -268,6 +288,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   origin: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -279,6 +300,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   pathname: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -290,6 +312,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   port: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -301,6 +324,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   protocol: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -312,6 +336,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   search: {
+    __proto__: null,
     get() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -323,6 +348,7 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     enumerable: true,
   },
   toString: {
+    __proto__: null,
     value: function toString() {
       const url = WeakMapPrototypeGet(workerLocationUrls, this);
       if (url == null) {
@@ -335,10 +361,12 @@ ObjectDefineProperties(WorkerLocation.prototype, {
     writable: true,
   },
   [SymbolToStringTag]: {
+    __proto__: null,
     value: "WorkerLocation",
     configurable: true,
   },
   [SymbolFor("Deno.privateCustomInspect")]: {
+    __proto__: null,
     value: function (inspect, inspectOptions) {
       return `${this.constructor.name} ${
         inspect({
diff --git a/ext/web/13_message_port.js b/ext/web/13_message_port.js
index d94ca13826..04697d6aa8 100644
--- a/ext/web/13_message_port.js
+++ b/ext/web/13_message_port.js
@@ -132,14 +132,17 @@ class MessagePort extends EventTarget {
   constructor() {
     super();
     ObjectDefineProperty(this, MessagePortReceiveMessageOnPortSymbol, {
+      __proto__: null,
       value: false,
       enumerable: false,
     });
     ObjectDefineProperty(this, nodeWorkerThreadCloseCb, {
+      __proto__: null,
       value: null,
       enumerable: false,
     });
     ObjectDefineProperty(this, nodeWorkerThreadCloseCbInvoked, {
+      __proto__: null,
       value: false,
       enumerable: false,
     });
diff --git a/ext/webgpu/01_webgpu.js b/ext/webgpu/01_webgpu.js
index 36b35072c6..bdabbdc32c 100644
--- a/ext/webgpu/01_webgpu.js
+++ b/ext/webgpu/01_webgpu.js
@@ -907,6 +907,7 @@ const GPUDeviceLostInfoPrototype = GPUDeviceLostInfo.prototype;
 function GPUObjectBaseMixin(name, type) {
   type.prototype[_label] = null;
   ObjectDefineProperty(type.prototype, "label", {
+    __proto__: null,
     /**
      * @return {string | null}
      */
diff --git a/ext/webidl/00_webidl.js b/ext/webidl/00_webidl.js
index 36fc89ce29..f23c9b7dd0 100644
--- a/ext/webidl/00_webidl.js
+++ b/ext/webidl/00_webidl.js
@@ -753,6 +753,7 @@ function createDictionaryConverter(name, ...dictionaries) {
         defaultValues[member.key] = member.converter(idlMemberValue, {});
       } else {
         ObjectDefineProperty(defaultValues, member.key, {
+          __proto__: null,
           get() {
             return member.converter(idlMemberValue, member.defaultValue);
           },
@@ -1076,6 +1077,7 @@ function mixinPairIterable(name, prototype, dataSymbol, keyKey, valueKey) {
   function createDefaultIterator(target, kind) {
     const iterator = ObjectCreate(iteratorPrototype);
     ObjectDefineProperty(iterator, _iteratorInternal, {
+      __proto__: null,
       value: { target, kind, index: 0 },
       configurable: true,
     });
@@ -1149,6 +1151,7 @@ function configureInterface(interface_) {
   configureProperties(interface_);
   configureProperties(interface_.prototype);
   ObjectDefineProperty(interface_.prototype, SymbolToStringTag, {
+    __proto__: null,
     value: interface_.name,
     enumerable: false,
     configurable: true,
@@ -1170,12 +1173,14 @@ function configureProperties(obj) {
       typeof descriptor.value === "function"
     ) {
       ObjectDefineProperty(obj, key, {
+        __proto__: null,
         enumerable: true,
         writable: true,
         configurable: true,
       });
     } else if (ReflectHas(descriptor, "get")) {
       ObjectDefineProperty(obj, key, {
+        __proto__: null,
         enumerable: true,
         configurable: true,
       });
@@ -1189,6 +1194,7 @@ const setlikeInner = Symbol("[[set]]");
 function setlike(obj, objPrototype, readonly) {
   ObjectDefineProperties(obj, {
     size: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       get() {
@@ -1197,6 +1203,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     [SymbolIterator]: {
+      __proto__: null,
       configurable: true,
       enumerable: false,
       writable: true,
@@ -1206,6 +1213,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     entries: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       writable: true,
@@ -1215,6 +1223,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     keys: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       writable: true,
@@ -1224,6 +1233,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     values: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       writable: true,
@@ -1233,6 +1243,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     forEach: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       writable: true,
@@ -1242,6 +1253,7 @@ function setlike(obj, objPrototype, readonly) {
       },
     },
     has: {
+      __proto__: null,
       configurable: true,
       enumerable: true,
       writable: true,
@@ -1255,6 +1267,7 @@ function setlike(obj, objPrototype, readonly) {
   if (!readonly) {
     ObjectDefineProperties(obj, {
       add: {
+        __proto__: null,
         configurable: true,
         enumerable: true,
         writable: true,
@@ -1264,6 +1277,7 @@ function setlike(obj, objPrototype, readonly) {
         },
       },
       delete: {
+        __proto__: null,
         configurable: true,
         enumerable: true,
         writable: true,
@@ -1273,6 +1287,7 @@ function setlike(obj, objPrototype, readonly) {
         },
       },
       clear: {
+        __proto__: null,
         configurable: true,
         enumerable: true,
         writable: true,
diff --git a/ext/websocket/01_websocket.js b/ext/websocket/01_websocket.js
index 60580a56ce..c55685ac93 100644
--- a/ext/websocket/01_websocket.js
+++ b/ext/websocket/01_websocket.js
@@ -627,15 +627,19 @@ class WebSocket extends EventTarget {
 
 ObjectDefineProperties(WebSocket, {
   CONNECTING: {
+    __proto__: null,
     value: 0,
   },
   OPEN: {
+    __proto__: null,
     value: 1,
   },
   CLOSING: {
+    __proto__: null,
     value: 2,
   },
   CLOSED: {
+    __proto__: null,
     value: 3,
   },
 });
diff --git a/ext/webstorage/01_webstorage.js b/ext/webstorage/01_webstorage.js
index 635e80d6ec..3cbdd708dd 100644
--- a/ext/webstorage/01_webstorage.js
+++ b/ext/webstorage/01_webstorage.js
@@ -119,6 +119,7 @@ function createStorage(persistent) {
     set(target, key, value) {
       if (typeof key === "symbol") {
         return ReflectDefineProperty(target, key, {
+          __proto__: null,
           value,
           configurable: true,
         });
diff --git a/runtime/js/40_fs_events.js b/runtime/js/40_fs_events.js
index a0495540c6..2140f29eb0 100644
--- a/runtime/js/40_fs_events.js
+++ b/runtime/js/40_fs_events.js
@@ -23,6 +23,7 @@ class FsWatcher {
   constructor(paths, options) {
     if (internals.future) {
       ObjectDefineProperty(this, "rid", {
+        __proto__: null,
         enumerable: false,
         value: undefined,
       });
@@ -79,7 +80,7 @@ class FsWatcher {
 
 function watchFs(
   paths,
-  options = { recursive: true },
+  options = { __proto__: null, recursive: true },
 ) {
   return new FsWatcher(ArrayIsArray(paths) ? paths : [paths], options);
 }
diff --git a/runtime/js/40_process.js b/runtime/js/40_process.js
index 954d8d00b3..358805180b 100644
--- a/runtime/js/40_process.js
+++ b/runtime/js/40_process.js
@@ -463,6 +463,7 @@ class Command {
 
   spawn() {
     const options = {
+      __proto__: null,
       ...(this.#options ?? {}),
       stdout: this.#options?.stdout ?? "inherit",
       stderr: this.#options?.stderr ?? "inherit",
diff --git a/runtime/js/98_global_scope_window.js b/runtime/js/98_global_scope_window.js
index aa18ed3613..27a3d309a8 100644
--- a/runtime/js/98_global_scope_window.js
+++ b/runtime/js/98_global_scope_window.js
@@ -60,6 +60,7 @@ const language = memoizeLazy(() => op_bootstrap_language());
 
 ObjectDefineProperties(Navigator.prototype, {
   gpu: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -69,6 +70,7 @@ ObjectDefineProperties(Navigator.prototype, {
     },
   },
   hardwareConcurrency: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -77,6 +79,7 @@ ObjectDefineProperties(Navigator.prototype, {
     },
   },
   userAgent: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -85,6 +88,7 @@ ObjectDefineProperties(Navigator.prototype, {
     },
   },
   language: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -93,6 +97,7 @@ ObjectDefineProperties(Navigator.prototype, {
     },
   },
   languages: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
diff --git a/runtime/js/98_global_scope_worker.js b/runtime/js/98_global_scope_worker.js
index 8e292108f8..4dc6157867 100644
--- a/runtime/js/98_global_scope_worker.js
+++ b/runtime/js/98_global_scope_worker.js
@@ -58,6 +58,7 @@ const workerNavigator = webidl.createBranded(WorkerNavigator);
 
 ObjectDefineProperties(WorkerNavigator.prototype, {
   gpu: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -67,6 +68,7 @@ ObjectDefineProperties(WorkerNavigator.prototype, {
     },
   },
   hardwareConcurrency: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -75,6 +77,7 @@ ObjectDefineProperties(WorkerNavigator.prototype, {
     },
   },
   userAgent: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -83,6 +86,7 @@ ObjectDefineProperties(WorkerNavigator.prototype, {
     },
   },
   language: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
@@ -91,6 +95,7 @@ ObjectDefineProperties(WorkerNavigator.prototype, {
     },
   },
   languages: {
+    __proto__: null,
     configurable: true,
     enumerable: true,
     get() {
diff --git a/runtime/js/99_main.js b/runtime/js/99_main.js
index d83bfbff12..2d5c96f6ab 100644
--- a/runtime/js/99_main.js
+++ b/runtime/js/99_main.js
@@ -92,12 +92,14 @@ if (Symbol.metadata) {
 }
 ObjectDefineProperties(Symbol, {
   dispose: {
+    __proto__: null,
     value: SymbolDispose,
     enumerable: false,
     writable: false,
     configurable: false,
   },
   metadata: {
+    __proto__: null,
     value: SymbolMetadata,
     enumerable: false,
     writable: false,
@@ -533,6 +535,7 @@ ObjectDefineProperties(finalDenoNs, {
   args: core.propGetterOnly(opArgs),
   mainModule: core.propGetterOnly(() => op_main_module()),
   exitCode: {
+    __proto__: null,
     get() {
       return os.getExitCode();
     },