diff --git a/cli/tests/integration/run_tests.rs b/cli/tests/integration/run_tests.rs
index f247aa93fb..f469bb3649 100644
--- a/cli/tests/integration/run_tests.rs
+++ b/cli/tests/integration/run_tests.rs
@@ -1185,6 +1185,13 @@ itest!(error_import_map_unable_to_load {
   exit_code: 1,
 });
 
+// Test that setting `self` in the main thread to some other value doesn't break
+// the world.
+itest!(replace_self {
+  args: "run replace_self.js",
+  output: "replace_self.js.out",
+});
+
 itest!(worker_event_handler_test {
   args: "run --quiet --reload --allow-read worker_event_handler_test.js",
   output: "worker_event_handler_test.js.out",
diff --git a/cli/tests/testdata/replace_self.js b/cli/tests/testdata/replace_self.js
new file mode 100644
index 0000000000..cfd473cd3f
--- /dev/null
+++ b/cli/tests/testdata/replace_self.js
@@ -0,0 +1,21 @@
+// Test that setting `self` in the main thread to some other value doesn't break
+// the world, in particular for events fired on the global scope.
+
+// deno-lint-ignore no-global-assign
+self = null;
+
+addEventListener("load", () => {
+  console.log("load event (event listener)");
+});
+
+addEventListener("unload", () => {
+  console.log("unload event (event listener)");
+});
+
+globalThis.onload = () => {
+  console.log("load event (event handler)");
+};
+
+globalThis.onunload = () => {
+  console.log("unload event (event handler)");
+};
diff --git a/cli/tests/testdata/replace_self.js.out b/cli/tests/testdata/replace_self.js.out
new file mode 100644
index 0000000000..aaffb5a62f
--- /dev/null
+++ b/cli/tests/testdata/replace_self.js.out
@@ -0,0 +1,4 @@
+load event (event listener)
+load event (event handler)
+unload event (event listener)
+unload event (event handler)
diff --git a/runtime/js/99_main.js b/runtime/js/99_main.js
index 32732923be..a895b0c57b 100644
--- a/runtime/js/99_main.js
+++ b/runtime/js/99_main.js
@@ -475,7 +475,7 @@ delete Object.prototype.__proto__;
     location: location.locationDescriptor,
     Window: globalInterfaces.windowConstructorDescriptor,
     window: util.readOnly(globalThis),
-    self: util.readOnly(globalThis),
+    self: util.writable(globalThis),
     Navigator: util.nonEnumerable(Navigator),
     navigator: {
       configurable: true,
@@ -628,7 +628,7 @@ delete Object.prototype.__proto__;
       ObjectDefineProperties(globalThis, unstableWindowOrWorkerGlobalScope);
     }
     ObjectDefineProperties(globalThis, workerRuntimeGlobalProperties);
-    ObjectDefineProperties(globalThis, { name: util.readOnly(name) });
+    ObjectDefineProperties(globalThis, { name: util.writable(name) });
     if (runtimeOptions.enableTestingFeaturesFlag) {
       ObjectDefineProperty(
         globalThis,
diff --git a/tools/wpt/expectation.json b/tools/wpt/expectation.json
index 511e1ddad9..8e631f4715 100644
--- a/tools/wpt/expectation.json
+++ b/tools/wpt/expectation.json
@@ -27840,7 +27840,7 @@
         "headers-normalize.any.html": true,
         "headers-record.any.html": true,
         "headers-structure.any.html": true,
-        "headers-basic.any.worker.html": false,
+        "headers-basic.any.worker.html": true,
         "headers-casing.any.worker.html": true,
         "headers-combine.any.worker.html": true,
         "headers-errors.any.worker.html": true,